Blood glucose levels and obesityBMI and disease

Pancreatic receptors are involved in negative feedback control of blood glucose through insulin, glucagon and adrenaline. People with type 1 diabetes are unable to produce insulin. In type 2 diabetes, individuals produce insulin but their cells are less sensitive to it. Obesity is a major risk factor for cardiovascular disease and type 2 diabetes.

Part of Human BiologyPhysiology and Health

BMI and disease

People with a very high body mass index (BMI) are defined as obese.

leads to high and the build-up of fatty deposits in the arteries, which leads to . It also increases the likelihood of developing , another risk factor for cardiovascular disease.

Being obese - with deposits of in the abdomen - increases blood pressure beyond normal levels and increases levels of blood lipids.

Type 2 diabetes

Body fat also affects the body's ability to use .

Type 2 diabetes is where the body's cells lose their sensitivity to insulin - they no longer respond, or respond less effectively, to the insulin that's produced. This causes glucose levels in the blood to rise to dangerous levels.

Obesity accounts for 80 to 85 per cent of the risk of type 2 diabetes. Rising obesity is linked with 'western diet' - a diet that includes energy-rich 'fast foods' and an inactive lifestyle. The bar charts show the increased risk of developing type 2 diabetes associated with people's body mass index (BMI).

The bar charts show the increased risk of developing Type 2 diabetes associated with people’s Body Mass Index.

There is no cure for type 2 diabetes, but it may be possible to control it by diet and exercise. The risk of developing cardiovascular disease and type 2 diabetes can be reduced by eating a balanced diet, with unrefined, unprocessed, 'whole foods', and taking regular exercise.